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pentobarbital will lower the level or effect of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to the decrease in fentanyl plasma concentrations, deficiency of efficacy or, possibly, progress of the withdrawal syndrome in a very pati